Microscopic Polyangiitis (MPA)

Understanding Microscopic Polyangiitis (MPA)

Microscopic Polyangiitis (MPA) is a rare autoimmune disease that leads to inflammation of small blood vessels (vasculitis). This inflammation can cause significant damage to various organs, particularly the kidneys, lungs, nerves, and skin. MPA is classified as an ANCA-associated vasculitis (AAV) because antineutrophil cytoplasmic antibodies (ANCA) mistakenly attack blood vessels, resulting in inflammation and tissue destruction.

Common Signs and Symptoms of MPA:

• Kidney Involvement:

  • Blood in the urine (hematuria)
  • Protein in the urine (proteinuria)
  • Reduced kidney function or kidney failure

• Lung Symptoms:

  • Shortness of breath or difficulty breathing
  • Cough, which may be accompanied by blood (pulmonary hemorrhage)

• General/Systemic Symptoms:

  • Fever
  • Fatigue and general malaise
  • Unintended weight loss
  • Muscle or joint aches

• Skin and Nerve Manifestations:

  • Skin rashes or purpura (small purple spots on the skin)
  • Nerve-related symptoms such as numbness or tingling

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.