Familial Mediterranean Fever (FMF)

Understanding Familial Mediterranean Fever (FMF)

Familial Mediterranean Fever (FMF) is a genetic autoinflammatory disorder that primarily affects individuals of Mediterranean descent, including those of Turkish, Armenian, Arab, Jewish, or Italian heritage. It is caused by mutations in the MEFV gene, which encodes the pyrin protein, leading to uncontrolled inflammation. This results in recurrent episodes of fever and pain, most commonly affecting the abdomen, chest, and joints. If left untreated, FMF can lead to complications such as amyloidosis, where abnormal proteins accumulate in organs, particularly the kidneys.

Common Signs and Symptoms of FMF:

• Recurrent Fevers:

  • Short, self-limited episodes of high fever, often accompanied by chills.

• Abdominal Pain:

  • Severe, cramping pain in the abdomen, sometimes associated with vomiting.

• Chest Pain:

  • Pleuritic chest pain or discomfort due to inflammation in the chest cavity.

• Joint Pain:

  • Episodes of arthritis or joint pain, particularly in the knees, ankles, or hips.

• Other Symptoms:

  • General malaise and fatigue during flare-ups.
  • In some cases, skin rashes may also occur.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.