Gastric or Gastroesophageal Junction (G/GEJ)

Understanding Gastric and Gastroesophageal Junction (GEJ) Cancers

Gastric (stomach) and gastroesophageal junction (GEJ) cancers are malignancies that develop in the lining of the stomach or at the area where the esophagus meets the stomach. These cancers are most often adenocarcinomas, arising from glandular cells. GEJ cancers are closely linked to chronic acid reflux (GERD), Barrett’s esophagus, and Helicobacter pylori (H. pylori) infection. They tend to be aggressive and are frequently diagnosed at advanced stages.

Common Signs and Symptoms of Gastric and GEJ Cancers:

• Persistent Indigestion or Heartburn: Ongoing discomfort or burning sensation in the chest or upper abdomen.
• Unexplained Weight Loss: Significant weight loss without changes in diet or exercise.
• Abdominal Pain: Discomfort or pain in the upper abdomen.
• Nausea and Vomiting: Recurrent nausea, vomiting, or difficulty swallowing.
• Loss of Appetite: A noticeable decrease in appetite, often leading to malnutrition.
• Fatigue: Persistent tiredness or weakness that affects daily activities.
• Anemia: Symptoms like pallor or shortness of breath, which may indicate internal bleeding.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.