
hATTR Amyloidosis
Hereditary ATTR (hATTR) amyloidosis is a rare progressive disease caused by a mutation in the transthyretin (TRR) gene. As a result, the TRR protein — which is made by the liver — is created with misfolds and accumulates as amyloid fibrils — peptides and proteins — on the nerves, digestive system, and/or the heart. When there’s an amyloid fibrils buildup, patients experience debilitating symptoms, which include:
Weakness of the limbs
Pain in the limbs
Loss of sensation
Swollen legs
Chest pain
Dizziness
Excessive sweating
Shortness of breath
Nausea
Vomiting
Constipation or diarrhea
Heart-related issues
Recurrent urinary tract infections (UTIs)
Carpal tunnel syndrome
Unintentional weight loss
Sexual dysfunction
Blurry vision
Floaters in the eye
Kidney disfunction
Dementia
Symptoms can vary from one person to another. They usually appear in adults between the ages of mid-20s to mid-60s, and they become more severe over time — disrupting everyday life and making it difficult to work.
Treatments perscribed by:
Referral Forms
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All Referral Forms