Transthyretin Amyloid Cardiomyopathy

Understanding Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a rare, progressive, and potentially life-threatening condition caused by the buildup of abnormal transthyretin (TTR) protein. This misfolded protein forms amyloid fibrils that deposit in the heart tissue, leading to stiffening of the heart walls, reduced cardiac function, and eventual heart failure. ATTR-CM may occur due to aging (wild-type) or inherited genetic mutations (hereditary).

Common Signs and Symptoms of ATTR-CM:

• Heart Failure Symptoms:Shortness of breath, fatigue, swelling in the legs or ankles, and reduced tolerance for physical activity due to decreased cardiac output.
• Arrhythmias:Irregular heartbeats or palpitations, sometimes requiring a pacemaker.
• Neuropathy:Numbness, tingling, or pain in the hands and feet, more common in hereditary forms.
• Carpal Tunnel Syndrome:Often occurs years before cardiac symptoms appear.
• Gastrointestinal Issues:Unintentional weight loss, early satiety, or diarrhea may occur in some patients.
• Orthostatic Hypotension:Dizziness or lightheadedness upon standing, due to autonomic nervous system involvement.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.