Acute Hepatic Porphyria (AHP)

Understanding Acute Hepatic Porphyria (AHP)

Acute Hepatic Porphyria (AHP) is a rare genetic disorder caused by defects in heme production, an essential component of hemoglobin. These defects lead to the accumulation of toxic porphyrin precursors in the liver, triggering severe neurovisceral attacks that can affect the nervous system and other organs.

Common Signs and Symptoms of AHP:

• Severe Abdominal Pain:

  • Intense, unexplained abdominal pain that may be accompanied by nausea and vomiting.

• Neurological Symptoms:

  • Peripheral neuropathy, tingling sensations, muscle weakness, or even seizures.

• Psychiatric Manifestations:

  • Anxiety, confusion, or mood changes during acute attacks.

• Autonomic Disturbances:

  • Rapid heart rate, high blood pressure, or excessive sweating during episodes.

• Other Systemic Symptoms:

  • Constipation, urinary retention, and general malaise that may occur during flare-ups.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.