Eosinophilic Granulomatosis with Polyangiitis (EGPA)

Understanding Eosinophilic Granulomatosis with Polyangiitis (EGPA)

Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare autoimmune vasculitis that causes inflammation of small to medium blood vessels, leading to tissue damage and organ dysfunction. It primarily affects the lungs, skin, heart, gastrointestinal tract, and nervous system, and is characterized by elevated levels of eosinophils (a type of white blood cell). EGPA most commonly develops in individuals with a history of asthma, allergic rhinitis, or sinusitis and typically progresses in three distinct stages:

• Prodromal Phase: Marked by asthma and allergic symptoms.
• Eosinophilic Phase: Characterized by an increase in eosinophils, leading to lung and gastrointestinal symptoms.
• Vasculitic Phase: Involves inflammation of blood vessels that can affect multiple organs.

Common Signs and Symptoms of EGPA:

• Respiratory Issues: Persistent asthma, wheezing, coughing, and shortness of breath.
• Allergic Symptoms: Allergic rhinitis, sinusitis, and nasal congestion.
• Skin Manifestations: Rashes, purpura, or other skin lesions.
• Gastrointestinal Symptoms: Abdominal pain, nausea, or diarrhea.
• Cardiac Concerns: Chest pain or other signs of heart involvement.
• Neurological Symptoms: Numbness, weakness, or other nerve-related issues.
• General Symptoms: Fatigue, fever, and unintentional weight loss.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.