Pemphigus Vulgaris (PV)

Understanding Pemphigus Vulgaris (PV)

Pemphigus Vulgaris (PV) is a rare, chronic autoimmune blistering disorder that affects both the skin and mucous membranes, including the mouth, throat, nose, and genitals. In PV, the immune system mistakenly produces autoantibodies against desmogleins—proteins that are essential for cell adhesion in the epidermis. This autoimmune attack leads to the formation of painful blisters and erosions, which can result in significant discomfort, increased risk of infection, and potential scarring if left untreated.

Common Signs and Symptoms of Pemphigus Vulgaris:

• Painful Blisters and Sores: Fluid-filled blisters that often rupture, leaving painful erosions on the skin and mucous membranes.
• Mucosal Involvement: Lesions in the mouth, throat, or other mucosal surfaces, which can interfere with eating, speaking, and swallowing.
• Skin Erosions: Areas of raw, open skin that may become infected.
• Crusting and Scaling: After blisters rupture, the affected areas may develop a crust or scale.
• General Discomfort: Persistent pain and irritation associated with the blisters and erosions.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.