Prophylaxis for Kidney Transplant Rejection

Understanding Organ Rejection

Organ rejection occurs when the recipient’s immune system recognizes the transplanted kidney as foreign and mounts an attack against it. Prophylaxis—using immunosuppressive medications, infusion therapies, and regular monitoring—is essential to suppress this immune response and help ensure the long-term survival of the transplanted kidney.

Rejection can occur in two forms:

• Acute Rejection: Typically occurs within weeks to months after transplantation.
• Chronic Rejection: Involves a gradual loss of kidney function over months or years.

Common Signs and Symptoms of Organ Rejection:

• Acute Rejection:

  • Sudden pain or tenderness over the transplant site
  • Swelling or redness near the transplanted kidney
  • Fever and flu-like symptoms
  • Decreased urine output or changes in urine appearance
  • Sudden increase in blood pressure

• Chronic Rejection:

  • Gradual decline in kidney function as shown by blood tests
  • Persistent fatigue and general malaise
  • Fluid retention, resulting in swelling (edema)
  • Ongoing high blood pressure

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.