Common Variable Immunodeficiency

Understanding Common Variable Immunodeficiency (CVID)

Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by low levels of immunoglobulins (antibodies), which makes it difficult for the immune system to effectively fight infections. As a result, individuals with CVID often experience recurrent infections, an increased likelihood of autoimmune diseases, and a higher risk of certain cancers. Although the exact cause remains unclear, genetic mutations affecting B-cell function are thought to play a significant role.

Common Signs and Symptoms of CVID:

• Recurrent Infections: Frequent episodes of respiratory infections such as pneumonia, bronchitis, sinusitis, and ear infections.
• Chronic Lung Issues: Persistent cough and potential complications like bronchiectasis due to repeated infections.
• Gastrointestinal Disturbances: Ongoing diarrhea, abdominal pain, or malabsorption issues.
• Autoimmune Manifestations: Conditions such as arthritis, autoimmune hemolytic anemia, or immune thrombocytopenia may occur.
• Lymph Node and Spleen Enlargement: Noticeable swelling in lymph nodes or the spleen.
• Persistent Fatigue: Continuous tiredness and low energy that impacts daily activities.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may experience with your physician.