Generalized Pustular Psoriasis (GPP)

Understanding Generalized Pustular Psoriasis (GPP)

Generalized Pustular Psoriasis (GPP) is a rare, severe, and potentially life-threatening form of psoriasis. It is characterized by widespread pustules (sterile blisters filled with pus) on inflamed, red skin. Unlike plaque psoriasis, which is driven by an overactive immune system targeting the skin, GPP is linked to genetic mutations that affect the immune response, particularly involving the IL-36 signaling pathway. GPP can occur in individuals with or without a history of psoriasis and typically presents in flare-ups that may be accompanied by systemic symptoms such as fever and organ involvement.

Common Signs and Symptoms of GPP:

• Widespread Pustules:
  • Numerous sterile pustules appear on areas of red, inflamed skin.
• Severe Skin Inflammation:
  • Extensive redness, swelling, and irritation of the skin.
• Systemic Symptoms:
  • Fever, chills, and a general feeling of being unwell may accompany skin flare-ups.
• Pain and Discomfort:
  • Significant discomfort or pain in affected areas, potentially impacting mobility and daily activities.
• Flare-Up Episodes:
  • Sudden, severe episodes of symptoms that may require urgent medical attention.
• Potential Organ Involvement:
  • In severe cases, systemic complications may occur, affecting other organs.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.