Still’s Disease (AOSD)

Understanding Adult-Onset Still’s Disease (AOSD)

Adult-Onset Still’s Disease (AOSD) is a rare autoinflammatory disorder characterized by high fevers, joint pain, and a distinctive salmon-colored rash. As a systemic inflammatory condition, AOSD can affect multiple organs, including the liver, spleen, and heart. Although the exact cause is unknown, it is thought to result from immune system dysregulation and the excessive production of inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-18 (IL-18). The severity of AOSD can vary widely—from mild and self-limited cases to severe, chronic forms that may lead to complications like macrophage activation syndrome (MAS), a potentially life-threatening condition.

Common Signs and Symptoms of AOSD:

• High Fevers: Recurrent, spiking fevers, often peaking once or twice daily.
• Joint Pain and Inflammation: Persistent joint pain, swelling, and stiffness.
• Salmon-Colored Rash: A pink or salmon-colored rash, typically appearing with fever spikes.
• Sore Throat: A persistent sore throat is commonly reported.
• Systemic Involvement: Signs of inflammation that may affect the liver, spleen, or lymph nodes.
• Fatigue and Malaise: Ongoing tiredness and a general feeling of being unwell.
• Potential Complications: In severe cases, watch for symptoms of macrophage activation syndrome (MAS), such as sudden worsening of fever, low blood counts, or liver dysfunction.

This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. Please discuss any symptoms you may exhibit with your physician.