
Cytokine Release Syndrome
Understanding Cytokine Release Syndrome (CRS)
Cytokine Release Syndrome (CRS) is a systemic inflammatory response that occurs when the immune system releases large amounts of cytokines into the bloodstream. This condition is commonly associated with immunotherapies, such as CAR-T cell therapy and monoclonal antibody treatments, but can also develop in response to infections, including severe viral or bacterial infections. If left untreated, CRS can cause life-threatening organ dysfunction.
Common Signs and Symptoms of Cytokine Release Syndrome
Flu-Like Symptoms:
- Fever: High temperature, often the first sign of CRS.
- Chills: Uncontrollable shaking or shivering.
- Fatigue: Persistent tiredness and weakness.
Inflammatory Symptoms:
- Low Blood Pressure (Hypotension): Can lead to dizziness, fainting, or shock.
- Rapid Heart Rate (Tachycardia): Increased heart rate due to systemic inflammation.
- Difficulty Breathing: Shortness of breath or low oxygen levels due to lung inflammation.
Neurological Symptoms:
- Confusion or Disorientation: Difficulty thinking clearly, memory issues.
- Headaches: Persistent or severe head pain.
- Seizures: In severe cases, CRS can trigger seizures.
Gastrointestinal Symptoms:
- Nausea and Vomiting: Can occur due to systemic inflammation.
- Diarrhea: Increased frequency of bowel movements.
- Loss of Appetite: Reduced desire to eat due to illness.
This information is provided as a resource and is not intended to diagnose a condition or prescribe treatment. If you notice any of these symptoms or have concerns about your health, please consult your physician.
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